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How mRNA Vaccines Work

A simpler development process and collaboration by human bodies are part of the breakthrough

Sanjay Mishra
Tue, 12/08/2020 - 12:02
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As the weather cools, the number of infections of the Covid-19 pandemic are rising sharply. Hamstrung by pandemic fatigue, economic constraints, and political discord, public health officials have struggled to control the surging pandemic. But now, a rush of interim analyses from pharmaceutical companies Moderna and Pfizer/BioNTech have spurred optimism that a novel type of vaccine made from messenger RNA, known as mRNA, can offer high levels of protection by preventing Covid-19 among people who are vaccinated.

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Submitted by zhangziping@ho… on Mon, 10/17/2022 - 19:38

question for Dr. Sanjay Mishra about How mRNA Vaccines Work

Dear Dr. Sanjay Mishra,

I have read your great article How mRNA Vaccines Work and have a question for you. When the genetic instructions of the viral protein are injected into the upper arm, the muscle cells translate them to make the viral protein directly in the body. Then, the spike protein built by the muscle cells will be considered a self-protein; how the immune system of the host body can recognize that it is different?

Please give me a reply. Thanks a lot!

Sincerely Yours,

Ziping Zhang

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