(Shimadzu: Columbia, MD) -- Shimadzu Scientific Instruments announces the LCMS-8065XE, the latest evolution in triple quadrupole mass spectrometry that redefines analytical excellence with world-class sensitivity, efficiency, and sustainability. This new instrument introduces innovative technologies that deliver exceptional performance with efficient and exact capabilities.

Technological advancements

StreamFocus ionization technology: The LCMS-8065XE features Shimadzu’s StreamFocus technology, a low-dispersion nebulizer nozzle that reduces liquid droplet dispersion while maximizing ion intake efficiency. This breakthrough reduces nebulizer gas consumption up to sevenfold compared to conventional ESI sources and achieves exceptional sensitivity improvements, particularly in negative mode.

Enhanced IonFocus performance: The evolved IonFocus unit utilizes a focusing electrode to selectively guide ions into the intake port while excluding neutral matrix components. This ensures sensitivity even when the ion spray is positioned farther from the intake port, enhancing robustness for long-term analysis.

UFsweeper IV collision cell: The next-generation collision cell features a larger inlet-lens diameter and more lenses for improved ion throughput, enhanced ion transmission, and improved sensitivity and quantitative precision.

Exceptional analytical performance

The LCMS-8065XE demonstrates remarkable capabilities with sub-ng/L detection limits for PFAS compounds in drinking water using direct injection. The system delivers three- to 48-fold sensitivity enhancement compared to previous-generation instruments while maintaining exceptional stability. More than 85% of initial response is retained after more than 10,000 consecutive injections of complex wastewater samples (RSD < 7%).

The instrument incorporates Shimadzu’s complete ultrafast mass spectrometry (UFMS) technology suite: world-class 5 msec positive/negative ion switching with zero signal loss, ultrafast MRM acquisition up to 555 channels/sec, scanning up to 30,000 u/sec with maximum ion transmittance, and advanced UF-Qarray II and UF-Lens II ion guides for maximum transmission efficiency.

AI-powered intelligence and sustainability leadership

Performance Concierge automatically monitors system performance, provides proactive maintenance alerts, and reduces instrument downtime through predictive diagnostics. Peak intelligence for LCMS delivers revolutionary AI-driven peak detection with up to 67% reduction in manual review time, and superior reproducibility across complex analyses.

The LCMS-8065XE leads in environmental responsibility with 31% power consumption reduction through intelligent Ecology Mode and 63% lower running costs compared to competitive systems (1,140 W with dry pump option). The system features quick maintenance without breaking vacuum, and minimal downtime.

Comprehensive PFAS analytical solution

The FluoroSuite provides a complete PFAS analysis solution with optional PFAS analysis kit for minimized background contamination, low-absorption shim-vial consumables, and support for EPA methods (533/537.1/1633), as well as ASTM 8421 and ISO 21675 regulatory methods. Integration with LabSolutions Insight enables automatic method optimization and intuitive workflow management.

Applications and availability

The LCMS-8065XE excels across environmental monitoring, food safety, pharmaceutical analysis, clinical research, and industrial quality control applications. The instrument is available immediately through Shimadzu’s North American network, along with comprehensive applications for development, training, and service support.

For more details, visit the LCMS-8065XE web page.