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NIST
Published: Wednesday, April 13, 2016 - 16:55 Researchers at the National Institute of Standards and Technology (NIST) have developed the first widely useful standard for magnetic resonance imaging (MRI) of the breast, a method used to identify and monitor breast cancer. The NIST instrument—a “phantom”—will help standardize MRIs of breast tissue and ensure quality control in comparing images within and between medical research studies. Phantoms mimic the response of human tissue to help test the performance of medical imaging systems. NIST’s new breast phantom also can be used to compare MRI scanners and train operators. The phantom supports quantitative MRI, which is increasingly used for breast cancer diagnosis, staging, and treatment monitoring, as well as for imaging other parts of the body. As described in a new paper, NIST’s prototype breast phantom was tested on MRI systems from two manufacturers in three configurations and produced accurate, quantitative images that could be used to evaluate common imaging procedures. Co-authors of the paper work at the University of California, San Francisco, where the phantom is already used in clinical trials. The NIST phantom is widely useful because it fits most major MRI scanner designs and meets a full range of common clinical imaging needs. In addition, like NIST’s other MRI phantoms, the breast phantom generates image data that can be traced to international measurement standards. Older breast phantoms don’t offer all these capabilities. The biggest design challenge was to create a lifelike mimic of both fat and fibroglandular tissue, NIST project leader Katy Keenan says. The design success led to industry’s rapid commercialization of the phantom, currently used by five research groups. “I believe the NIST phantom can have a big impact, especially because we are seeing more use of quantitative MRI for breast cancer,” Keenan says. “It will be used by both researchers developing new techniques and by radiologists using techniques in the clinic.” The phantom has a flexible, modular design. The soft silicone shell (15 cm × 12.5 cm) enables fitting to different MRI scanners. Internal components are made of rigid polycarbonate to ensure regular geometry. The phantom has two basic types of internal arrangements that can be paired for MRI scans. One unit is designed for conventional MRI scans based on magnetic properties of hydrogen atoms. This unit contains four layers of small plastic spheres filled with tissue mimics: corn syrup in water to represent fibroglandular tissue, and grapeseed oil to represent fat. The spheres can be customized to meet special clinical needs. Potential future options include solutions that would mimic either benign cysts or tiny bits of calcium, called microcalcifications, that can signal cancer. The second phantom unit is designed for the newer technique of diffusion MRI that measures the motion of water molecules within the breast. This unit contains plastic tubes filled with varying concentrations of a nontoxic polymer (polyvinylpyrrolidone), similar to NIST’s diffusion MRI phantom. The solutions are tuned to mimic the differing diffusion properties of malignant tumors vs. benign tumors. Researchers continue to work on the NIST breast phantom. For instance, natural oils such as grapeseed oil can vary in consistency, so a different fat tissue mimic has been developed, a synthetic oil that remains stable across production batches and over time. In addition, a multisite trial is planned to examine measurement variations at clinical imaging centers. Quality Digest does not charge readers for its content. We believe that industry news is important for you to do your job, and Quality Digest supports businesses of all types. However, someone has to pay for this content. And that’s where advertising comes in. Most people consider ads a nuisance, but they do serve a useful function besides allowing media companies to stay afloat. They keep you aware of new products and services relevant to your industry. All ads in Quality Digest apply directly to products and services that most of our readers need. You won’t see automobile or health supplement ads. So please consider turning off your ad blocker for our site. Thanks, Founded in 1901, the National Institute of Standards and Technology (NIST) is a nonregulatory federal agency within the U.S. Department of Commerce. Headquartered in Gaithersburg, Maryland, NIST’s mission is to promote U.S. innovation and industrial competitiveness by advancing measurement science, standards, and technology in ways that enhance economic security and improve our quality of life.Researchers Develop First Widely Useful Standard for Breast MRI
NIST ‘phantom,’ mimics human breast tissue response to test MRI systems
NIST engineer Katy Keenan holds a new “phantom” that will help standardize magnetic resonance imaging (MRI) of the breast. This phantom mimics the response of human breast tissue to test the performance of MRI systems, and it may be used to ensure quality control when comparing images within and between medical research studies. Credit: von Dauster/NIST
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